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These tails are topic to several put up-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, lawyers in my area sumoylation and methylation (reviewed in 1 ). Methylation been discovered on a range of lysine residues in numerous histones: K4 (using the single-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, law K20 in histone H4, K59 within the globular domain of histone H4 2 and K26 of histone H1B three Several proteins liable for the methylation of specific residues have been characterized, and all however one in every of these comprises a SET area