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Methylation been discovered on a spread of lysine residues in numerous histones: K4 (using the only-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 in the globular domain of histone H4 2 and K26 of histone H1B 3 Several proteins chargeable for the methylation of specific residues have been characterised, and all but certainly one of these comprises a SET domain