A) Discrimination factors of NSD1 for the recognition of amino acid residues on the positions subsequent to the goal lysine (K36 within the experiment proven right here). These tails are topic to several put up-translational covalent modifications, together with acetylation, phosphorylation, ubiquitination, sumoylation and methylation (reviewed in 1 ).

Lysine is a vital amino acid.

The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and that are structurally not related to SET-domain proteins 4 - 6 Recent work means that SET-domain-containing proteins methylate just a few proteins along with histones (see later)